Helly Patel

• Led the development of assembloid-based models for organogenesis and liver fibrosis research using iPSCs, advancing tissue
regeneration and disease modeling techniques.
• Conducted cell culture and differentiation experiments, creating and merging spheroids from HEPG2-WT, fibroblasts (MRC5,
HFF), and iPSCs to form Assembloids, while optimizing protocols for tissue engineering applications.
• Performed qPCR, immunofluorescence, cellular viability assays, and ImageJ analysis to assess the impact of drug inhibition on
liver development, focusing on critical signaling pathways in liver organogenesis.
• Trained and supervised over 10 team members in advanced molecular biology techniques, ensuring lab safety compliance and
promoting experimental rigor in BSL-2 laboratory environments.
• Published key findings on in vitro liver organogenesis and Assembloids formation, significantly contributing to the field of
synthetic tissue engineering and liver fibrosis treatment research.

• Focused on pulmonary fibrosis, the project aimed to isolate Extracellular Matrix (ECM) from human lung tissue using both oneday
and three-day decellularization protocols to assess their impact on tissue integrity and future biomedical applications.
• Executed precise decellularization processes and induced hypertension in porcine heart tissues, followed by comprehensive
biochemical characterization of the ECM to evaluate its potential for drug testing, recellularization, and scaffold preparation.
• Conducted a range of biochemical assays and mechanical testing, quantifying DNA, collagen, and glycosaminoglycans to compare
the structural and biochemical properties of ECM isolated through short-term and extended decellularization protocols.
• Generated detailed lab reports, critically analyzing the biomechanical and biochemical properties of ECM to refine
decellularization techniques and enhance the reproducibility of results in future tissue engineering and fibrosis research.
• Demonstrated superior biochemical and structural outcomes with the three-day decellularization method, providing valuable
insights for the optimization of ECM-based scaffolds in therapeutic applications, including drug screening and recellularization
strategies.

• I started off as a junior consultant, quickly got promoted to senior consultant, and then worked as a supervisor.
• Interacted with various customers and developed mindedness, confidence, communication, and listening skills.
• Responsible for managing and training incoming consultants to retain the best level of customer service.
• Handled sensitive data with exclusive authorization to assist Students, Faculty, and Staff.

• Provided excellent customer service at various food stations at University at Buffalo.
• Collaborated with diverse team members from around the globe to ensure smooth operations.
• Successfully passed the Payment Card Industry Data security test to ensure data protection.